Khoury founded Jean Pierre Khoury Studios, a Beirut-based fashion house, in late 2019. His designs have been worn by celebrities including Beyoncé, Arden Cho, Nicki Minaj, Yasmine Sabri, Karolina Kurkova, Miranda Kerr, Sophia Bush, Halle Bailey, Nora Fatehi, Dorra Zarrouk, and Najwa Karam. He was responsible for Myriam Fares outfits in the official anthem music video for FIFA World Cup Qatar 2022™ as well as for her opening concert performance. In 2026, Khoury plans to launch an evening and bridal ready-to-wear (RTW) line, expanding his fashion house’s offerings.