Acra’s talent was first discovered by a fashion editor at a party while she was still a student at the American University of Beirut. She debuted her designs at her first fashion show only ten days later. In 1997, Acra’s first bridal design was worn by a high-profile socialite. She established her eponymous line, Reem Acra New York, in the same year. Acra launched her first ready-to-wear collection in 2001. Her designs have been seen on celebrities such as U.S. First Lady Jill Biden, Princess Beatrice of York, and Poorna Jagannathan.