Sajwani is the chairman of Dubai-based luxury real estate developer DAMAC Properties, which he founded in 2002. He started out in the food services business, catering to the U.S. military and construction giant Bechtel. In 2001, after Dubai allowed foreigners to own property, he shifted to real estate and sold units in a residential building in less than six months. As of March 2025, DAMAC Properties had delivered over 48,000 units and developed over 50,000. It has projects in over 15 countries, including the U.A.E., Saudi Arabia, the U.K., and the U.S. In 2025, Sajwani also announced plans to invest $20 billion in building data centers in the U.S. through EDGNEX Data Centers by DAMAC, with potential plans to double the investment.