Reem Acra was first discovered by a fashion editor at a party she attended wearing one of her own designs. She launched Reem Acra New York in 1997, first entering the bridal market. She established her ready-to-wear collection in 2001. Acra collaborated with Snapchat to launch her spring 2021 collection, enabling brides to try on wedding dresses using the app before booking an appointment with the brand. Her designs have been worn by celebrities such as Angelina Jolie, Taylor Swift, Jennifer Lopez, Beyonce, Halle Berry, and Selena Gomez, appearing on red carpets at the Oscars, Grammys, and Golden Globes.